How to Build a Human: Adventures in How We Are Made and Who We Are

How to Build a Human: Adventures in How We Are Made and Who We Are
Philip Ball

A cutting-edge examination of what it means to be human and to have a 'self' in the face of new scientific developments in cloning, gene-splicing and neural downloading.After seeing his own cells used to grow clumps of new neurons – essentially mini-brains – Philip Ball begins to examine the concepts of identity and consciousness. Delving into humanity's deep evolutionary past to look at how complex creatures like us emerged from single-celled life, he offers a new perspective on how humans think about ourselves. In an age when we are increasingly encouraged to regard the 'self' as an abstract sequence of genetic information, or as a pattern of neural activity that might be 'downloaded' to a computer, I return us to the body – to flesh and blood – and anchor a conception of personhood in this unique and ephemeral mortal coil. How to Build a Human brings us back to ourselves – but in doing so, it challenges old preconceptions and values. It asks us to rethink how we exist in the world.

Copyright (#ulink_1d430c2c-c48a-54da-bb69-435fe1bd632b)

William Collins

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This eBook first published in Great Britain by William Collins in 2019

Copyright © Philip Ball 2018

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Source ISBN: 9780008331771

Ebook Edition © May 2019 ISBN: 9780008331795

Version: 2019-05-20

CONTENTS

COVER (#uc01781a3-1632-565a-b694-271edf0350e9)

TITLE PAGE (#ue737d414-ea55-5bc8-bcb3-f2f5bb1af3a3)

COPYRIGHT (#u6ae021f4-ed3a-5450-b361-abbb50f0f969)

PROLOGUE (#u66f04db0-b842-5c96-b383-7c001310537c)

INTRODUCTION (#uc1e397c8-8007-5673-8d70-0b59b67d685a)My Brain in a Dish (#uc1e397c8-8007-5673-8d70-0b59b67d685a)

CHAPTER 1 (#u502fb726-e0d8-5021-8b01-53b94fe27c4e)Pieces of Life (#u502fb726-e0d8-5021-8b01-53b94fe27c4e)Cells past and present (#u502fb726-e0d8-5021-8b01-53b94fe27c4e)

CHAPTER 2 (#u51a97aac-896f-50af-8483-ff142cff07f3)Body Building (#u51a97aac-896f-50af-8483-ff142cff07f3)Growing humans the old-fashioned way (#u51a97aac-896f-50af-8483-ff142cff07f3)

FIRST INTERLUDE (#u342d2db8-930e-5626-99ea-5e5671515789)The Human Superorganism (#u342d2db8-930e-5626-99ea-5e5671515789)How cells became communities (#u342d2db8-930e-5626-99ea-5e5671515789)

CHAPTER 3 (#litres_trial_promo)Immortal Flesh (#litres_trial_promo)How tissues were grown outside the body (#litres_trial_promo)

SECOND INTERLUDE (#litres_trial_promo)Heroes and Villains (#litres_trial_promo)Cancer, immunity and our cellular ecosystem (#litres_trial_promo)

CHAPTER 4 (#litres_trial_promo)Twists of Fate (#litres_trial_promo)How to reprogramme a cell (#litres_trial_promo)

CHAPTER 5 (#litres_trial_promo)The Spare Parts Factory (#litres_trial_promo)Making tissues and organs from reprogrammed cells (#litres_trial_promo)

CHAPTER 6 (#litres_trial_promo)Flesh of My Flesh (#litres_trial_promo)Questioning the future of sex and reproduction (#litres_trial_promo)

CHAPTER 7 (#litres_trial_promo)Hideous Progeny? (#litres_trial_promo)The futures of growing humans (#litres_trial_promo)

THIRD INTERLUDE (#litres_trial_promo)Philosophy of the Lonely Mind (#litres_trial_promo)Can a brain exist in a dish? (#litres_trial_promo)

CHAPTER 8 (#litres_trial_promo)Return of the Meatware (#litres_trial_promo)Coming to terms with our fleshy selves (#litres_trial_promo)

FOOTNOTES (#litres_trial_promo)

ENDNOTES (#litres_trial_promo)

BIBLIOGRAPHY (#litres_trial_promo)

PICTURE CREDITS (#litres_trial_promo)

INDEX (#litres_trial_promo)

ACKNOWLEDGEMENTS (#litres_trial_promo)

ABOUT THE BOOK (#litres_trial_promo)

ABOUT THE AUTHOR (#litres_trial_promo)

ABOUT THE PUBLISHER (#litres_trial_promo)

PROLOGUE (#ulink_d08954e3-f03b-574b-9b3d-36536c989882)

This book arose from an astonishing experiment in which I was invited to take part, and which involved the transformation of a piece of me.

In the course of writing it, as I spoke to scientists about cell biology and fertility, embryology and medicine, philosophy and ethics, it dawned on me just how much science, in these fields especially, is driven by stories.

I don’t mean “human stories” – those tales about people that are said to be so central to keeping general audiences engaged. I mean that our perception of what science means is shaped by narratives about it. There are narratives that society imposes on new discoveries and advances, which are often cut from older cloth. In biology – particularly developmental, cell and reproductive biology – these stories tend to come from myth, science fiction and fantasy, and they are often alarming: they might, for example, draw on Frankenstein, Brave New World, The Island of Doctor Moreau. But there are also narratives that scientists themselves create and recycle. It happens more in the biological sciences than in the others because biology is inherently a science of becoming, where history matters and where we seem compelled to speak about goals and purposes: what organisms, cells and genes “want”, what evolution “seeks to do”.

A significant aspect of this book’s aim is to expose and explore these stories. They are by no means a bad thing. On the contrary, they are essential and often illuminating, for they fit with the way we humans make sense of our world, with our instinct to look for and find causation, reasons behind things. Yet there is a danger to them too, which is that we might begin to mistake them for descriptions of how things are.

One of the classic examples of a framing narrative in biology is Richard Dawkins’s concept of the selfish gene. Dawkins has had to defend this idea against accusations that it attributes a kind of agency and intention to genes, for it is of course just a metaphor. The problem is that, when a metaphor gets this popular, it starts to be understood (and sometimes presented) as a plain account of “what things are like”. When Dawkins speaks of us – individual humans – as the “survival machines” for genes, he is not defining what a human is but is explaining what we are required to be within the narrative of the selfish gene. The narrative serves to convey a particular aspect of how genes function in evolutionary terms. If you don’t like this story, or don’t find it helpful, you are not obliged to accept it; there is nothing “real” about it. Dawkins has said as much: he admits in The Selfish Gene that it should strictly be called The Slightly Selfish Big Bit of Chromosome (#litres_trial_promo) and the Even More Selfish Little Bit of Chromosome. (He was right to suspect the book would not have been so successful if he’d called it that.) He even admitted much later that the book could equally have been titled The Cooperative Gene. That would have been a different narrative, of course, and it would have served to illustrate another facet of how genes work.

As Dawkins implicitly acknowledgeshere, biology is too complex and complicated to be reduced to a single story. That’s precisely why we need stories to tell about it: they give us something to cling to, some way of finding a path through the thicket. There is almost always more than one of them.